There are a few factors that may increase the risk of developing pancreatic cancer, including obesity, diabetes, smoking, eating processed meats, and being over the age of 60. Contrary to the heart or the lungs, which we feel every day working in our bodies, the pancreas is a silent gland that rarely gets mentioned. Imaging tests that create pictures of your internal organs. Patients will be assigned to different baskets according to tumor type and gene fusion. BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: the COMBAT trial Nat Med. High-grade neuroendocrine carcinoma (pancreatic neuroendocrine tumor [PNET] should be enrolled in Cohort 22; prostatic neuroendocrine carcinomas should be enrolled into Cohort 52). It is estimated that 23% of individuals survive one year after the diagnosis, and only 8% are living five years post-diagnosis. Catching pancreatic cancer in earlier stages improves one's chance for survival, but University of Cincinnati researchers wanted to know if administering chemo before surgery in some patients, in addition to after, would make a difference. These proteins help repair damaged deoxyribonucleic acid (DNA) and, therefore, play a role in ensuring the stability of each cell’s genetic material. Pancreatic cancer is diagnosed through a combination of clinical history, imaging tests to look for any tumors or masses in or around the pancreas, lab tests, and a biopsy of any masses that were found. The other main function of the pancreas is to aid with digestion. Anetumab attaches to mesothelin positive cancer cells in a targeted way and delivers DM4 to kill them. "Pancreatic Cancer Diagnostic Tests - Medical Devices Pipeline Assessment, 2020" provides comprehensive information about the Pancreatic Cancer Diagnostic Tests pipeline products with comparative analysis of the products at various stages of development and information about the clinical trials … In our urgent mission to save lives, we attack pancreatic cancer on all fronts: research, clinical initiatives, … All clinical trials are different, so while some clinical trials only evaluate the participants a few times per week or per month, other studies (especially cancer clinical trials) are inpatient clinical trials, which mean that the participant will be admitted to the hospital for the duration of the study. Location: 204 locations, This phase II trial studies whether adding pembrolizumab to olaparib (standard of care) works better than olaparib alone in treating patients with pancreatic cancer with germline BRCA1 or BRCA2 mutations that has spread to other places in the body (metastatic). As a result, cells are more likely to develop additional genetic alterations that can lead to some types of cancer, including pancreatic cancer. This is one of the reasons why this is one of the most aggressive types of cancer. The study objectives are to assess the safety, tolerability and pharmacokinetics (PK) of the oral RAD51 inhibitor CYT-0851 in patients with relapsed / refractory B-cell malignancies and advanced solid tumors and to identify a recommended Phase 2 dose for evaluation in these patients. Techniques used to diagnose pancreatic cancer include ultrasound, computerized tomography (CT) scans, magnetic resonance imaging (MRI) and, sometimes, positron emission tomograp… Location: 11 locations, This is a Phase 1, multiple dose, ascending-dose escalation study and expansion study designed to define a maximum tolerated dose and / or recommended dose of XmAb22841 monotherapy and in combination with pembrolizumab; to assess safety, tolerability, pharmacokinetics, immunogenicity, and anti-tumor activity of XmAb22841 monotherapy and in combination with pembrolizumab in subjects with select advanced solid tumors. Small cell carcinoma of the ovary, hypercalcemic type 49. Location: 13 locations, This is a Phase 3, randomized, double-blind trial to evaluate the efficacy and safety of neoadjuvant treatment with pamrevlumab or placebo in combination with gemcitabine plus nab-paclitaxel (G / NP) in the treatment of locally advanced, unresectable pancreatic cancer subjects. Gestational trophoblastic disease (GTD) 47. Non-epithelial tumors of the ovary: A) Germ cell tumor of ovary B) Mullerian mixed tumor and adenosarcoma (closed to accrual 03 / 30 / 2018) 14. These tests help your doctors visualize your internal organs, including the pancreas. The addition of pembrolizumab to the usual treatment of olaparib may help to shrink tumors in patients with metastatic pancreatic cancer with BRCA1 or BRCA2 mutations. Location: 9 locations, Treatment Clinical Trials for Pancreatic Cancer, Complementary & Alternative Medicine (CAM), Coping with Your Feelings During Advanced Cancer, Late Effects of Childhood Cancer Treatment, Frederick National Laboratory for Cancer Research, Milestones in Cancer Research and Discovery, Tech Transfer & Small Business Partnerships, Step 1: Application Development & Submission, How to Work With Your Health Insurance Plan, Questions to Ask about Treatment Clinical Trials, Drugs Approved for Different Types of Cancer, Drugs Approved for Conditions Related to Cancer, Targeted Therapy Directed by Genetic Testing in Treating Patients with Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial), Nivolumab and Ipilimumab in Treating Patients with Rare Tumors, Comparing Two Treatment Combinations, Gemcitabine and Nab-Paclitaxel with 5-Fluorouracil, Leucovorin, and Liposomal Irinotecan for Older Patients with Pancreatic Cancer That Has Spread, Testing the Use of the Usual Chemotherapy before and after Surgery for Removable Pancreatic Cancer, Testing the Addition of Pembrolizumab, an Immunotherapy Cancer Drug to Olaparib Alone as Therapy for Patients with Pancreatic Cancer That Has Spread with Inherited BRCA Mutations, Testing the Combination of Anetumab Ravtansine With Either Nivolumab, Nivolumab and Ipilimumab, or Gemcitabine and Nivolumab in Advanced Pancreatic Cancer, Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1 / 2 / 3 (Trk A / B / C), ROS1, or ALK Gene Rearrangements (Fusions), A Study of a Personalized Cancer Vaccine Targeting Shared Neoantigens. Peripheral nerve sheath tumors and NF1-related tumors (closed to accrual 09 / 19 / 2018) 29. Giving anetumab ravtansine together with nivolumab, ipilimumab, and gemcitabine hydrochloride may work better in treating patients with pancreatic cancer. Symptoms for pancreatic cancer … Location: 1201 locations, This phase II trial studies nivolumab and ipilimumab in treating patients with rare tumors. Salivary gland type tumors of head and neck, lip, esophagus, stomach, trachea and lung, breast and other location (closed to accrual) 4. Location: 13 locations, This clinical trial is an interventional, active-treatment, open-label, multi-center, Phase 1 / 2 study. Desmoid tumors 28. Location: 10 locations, This is a Phase 1, open-label, dose-escalation study to evaluate the safety, tolerability, pharmacokinetic, pharmacodynamic and clinical activity of AB680 in combination with Zimberelimab (AB122), nab-paclitaxel and gemcitabine in participants with advanced pancreatic cancer. Location: 42 locations, This phase I trial studies the side effects and best dose of anetumab ravtansine when given together with nivolumab, ipilimumab and gemcitabine hydrochloride in treating patients with mesothelin positive pancreatic cancer that has spread to other places in the body (advanced). This trial will study the safety, tolerability, pharmacokinetics, and anti-tumor activity of TTX-030 as a single agent and in combination with an approved anti-PD-1 immunotherapy and standard chemotherapies. Epub 2020 … Genetic tests look at the unique genetic material (genes) of patients' tumor cells. Eibl and Sahin-Toth are committed to illuminating the role of pancreatic inflammation in cancer development and exploring potential interventions that could thereby reduce cancer risk. Clear cell cervical cancer 43. Chemotherapy drugs, such as fluorouracil, irinotecan, leucovorin, and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. There are two parts to this study. Cell tumor of the testes and extragonadal germ tumors: A) Seminoma and testicular sex cord cancer B) Non-seminomatous tumor C) Teratoma with malignant transformation (closed to accrual) 17. Some cancer clinical trials have been designed to improve the way doctors diagnose pancreatic cancer and to look for ways to diagnose the disease early in order to improve the patient’s prognosis. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. 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